Ankylosing Spondylitis

What is Ankylosing Spondylitis?

Ankylosing spondylitis (AS) is a type of inflammatory arthritis that primarily affects the spine, causing pain, stiffness, and reduced mobility. Over time, AS can lead to the fusion of spinal vertebrae, limiting flexibility and causing a hunched posture. AS is an autoimmune condition with no known cure, but early diagnosis and treatment can help manage symptoms and prevent progression.

Symptoms of Ankylosing Spondylitis May Include:

• Chronic back pain and stiffness, especially in the lower back and hips
• Pain that worsens after periods of rest or inactivity
• Reduced spinal flexibility
• Fatigue and discomfort in other joints, such as shoulders or hips
• In severe cases, fusion of the spine

Facts About Ankylosing Spondylitis

• AS affects approximately 1 in 200 adults, with symptoms often appearing between the ages of 15 and 30.
• Men are more commonly affected than women.
• Early signs of AS may be mistaken for other forms of back pain, delaying diagnosis.

Who is at Risk for Ankylosing Spondylitis?

Risk factors for ankylosing spondylitis may include:

• Genetics: A strong familial link is associated with the HLA-B27 gene, which increases risk.
• Sex: Men are more likely to develop AS than women.
• Age: Symptoms often begin in late adolescence or early adulthood.
• Race or Ethnicity: AS is more common in Caucasian and Asian populations.
• Other Risk Factors: Smoking may exacerbate symptoms and increase disease progression.

Diagnosis & Management

AS is typically diagnosed using a combination of patient history, physical exams, imaging tests (X-rays or MRIs), and blood tests to check for markers like HLA-B27. Early diagnosis is crucial for managing symptoms and preventing irreversible spinal damage.

Treatment Options for Ankylosing Spondylitis

Medical and Pharmaceutical Treatments

• Medications: Nonsteroidal anti-inflammatory drugs (NSAIDs), TNF inhibitors, and IL-17 inhibitors are commonly prescribed.
• Injections: Corticosteroid injections may help reduce localized inflammation.
• Surgical Options: In rare cases, corrective surgery may be needed to address severe spinal deformities.

Lifestyle Interventions

• Physical Therapy: Regular exercises and stretches help maintain spinal mobility and posture.
• Posture Training: Awareness and correction of posture can reduce strain on the spine.
• Smoking Cessation: Quitting smoking can slow disease progression and improve overall health.

Have You Been Diagnosed With Ankylosing Spondylitis?

At Clinical Investigation Specialists, Inc. (CIS Research), we are committed to advancing medical care through innovative clinical research. You may be eligible for a clinical trial exploring new treatment options for ankylosing spondylitis. For more information on currently enrolling studies, click here.

Resources

• Spondylitis Association of America (SAA)
• Arthritis Foundation
• Find A Study
• Learn More About Clinical Research